Learn about Valdoxan (agomelatine), a mental health medication
Valdoxan (agomelatine) is used to treat depression, anxiety, and other mental health conditions. Like all medications for the management of mental health, it comes with its own side effects, contraindications, and other guidelines.
Learn about this medication with Chemist2U today.
In this article
How does Valdoxan (agomelatine) work?
Valdoxan (agomelatine) is used in the treatment of depression and anxiety. Available only with a doctor’s prescription, this antidepressant not only targets the symptoms but also focuses on the underlying disruptions in your body’s natural rhythms.[1]
It works to restore your sleep cycle and positively impact your mood and sleep patterns, which are often disturbed by depression and anxiety. By stimulating MT1 and Mt2 receptors, Agomelaine helps regulate circadian rhythms involved in sleep while also blocking 5 -HT2C receptors in the brain to help increase dopamine and noradrenaline levels.
These neurotransmitters are like messengers that help nerve cells communicate, playing a crucial role in regulating mood. By enhancing their presence, Valdoxan serves as an insomnia remedy, helping to alleviate the burdensome symptoms of depression while potentially normalising sleep patterns – a vital aspect of mental health recovery.[3]
Agomelatine’s effect on melatonin receptors also translates to improved sleep quality without causing daytime grogginess. Clinical studies show changes in sleep electroencephalograms, highlighting improvements in sleep architecture.[4]
Essentially, Valdoxan (agomelatine) may not only aid in managing mood and anxiety but may also help synchronise your circadian rhythms, supporting a holistic approach to mental well-being. People interested in learning more about Prozac (fluoxetine) and Cymbalta (duloxetine) may also find it helpful to learn about this anxiety medication and depression treatment.
How do you take Valdoxan (agomelatine)?
The usual prescription is one tablet at bedtime, though your doctor may adjust this depending on your specific needs.[5] It’s important to follow your doctor’s guidance and not exceed their recommended dose, even if you’re feeling better. Remember, any changes to your medication should always be under your doctor’s advice.
A study involving 180 patients with major depressive disorder (MDD) highlighted the efficacy of agomelatine. Over twelve weeks, patients taking the medication showed faster improvement within the first two weeks and fewer adverse reactions compared to those on SSRIs.[6] Agomelatine is generally well-tolerated, not affecting sexual function or causing weight gain – two common concerns with antidepressants.[7]
Who can take Valdoxan (agomelatine)?
Valdoxan (agomelatine) is typically prescribed for those grappling with MDD, generalised anxiety disorder, and other mental health conditions. It’s crucial, however, to understand that it is not suitable for everyone.
Agomelatine is contraindicated in individuals who have liver diseases or liver impairment. To ensure safety, liver function tests are a must at the start of the treatment and periodically thereafter.[8]
Your health history plays a significant role in determining if medications like Valdoxan (agomelatine) are right for you. Inform your doctor if you’ve ever experienced bipolar disorder, mania, hypomania, or if there’s a history of dementia. Pregnancy, plans for pregnancy, and breastfeeding are critical discussions to have with your doctor before starting this medication.[9]
Additionally, your alcohol consumption and smoking habits – particularly if you smoke more than fifteen cigarettes a day – are essential factors to consider.[10]
Side effects of Valdoxan (agomelatine)
The side effects of taking Valdoxan (agomelatine) are generally mild and often temporary. Commonly, within the first two weeks, some individuals may experience nausea and dizziness. Other side effects can include somnolence (a state of drowsiness), insomnia, migraine headaches, anxiety, constipation, diarrhea, fatigue, back pain, and hyperhidrosis (excessive sweating).[11]
Valdoxan (agomelatine) and other medications
When considering mental health medications or when using a mood enhancer or melatonin alternative as part of your treatment, keep your doctor informed about all other medications you’re taking.
This includes not only prescription drugs but also any over-the-counter medicines, vitamins, or supplements from your pharmacy, supermarket, or health food store.
Some medications can interact with Valdoxan (agomelatine), affecting how it works. Some may even increase the effect of this medication. These include, but are not limited to, medicines like fluvoxamine (used for depression), ciprofloxacin (an antibiotic), and propranolol (sometimes used for heart problems).[12]
These interactions are important to understand for your safety and the effectiveness of your treatment. An open dialogue with your doctor or pharmacist about all your current medications can help them provide you with the most accurate and personalised advice on how these might impact your Valdoxan treatment.
Medicines you should not use with Valdoxan (agomelatine)
This medication is contraindicated in patients who have shown hypersensitivity to agomelatine or have a history of liver issues, such as cirrhosis or active liver disease. The same is true for patients whose liver enzyme levels are more than three times the normal upper limit.[13]
It is also contraindicated for patients taking potent CYP1A2 inhibitors, which include medications like fluvoxamine (often used for depression) and ciprofloxacin (an antibiotic).[14]
How to order Valdoxan (agomelatine) through Chemist2U
Ordering your prescription medication and over-the-counter goods is effortless with Chemist2U.
Simply download our user-friendly app or use this website to begin. Here, you can conveniently upload your eScript and explore a wide range of general pharmacy products. Add what you need to your order, and rest assured a trusted local pharmacist will meticulously prepare it.
We’re committed to bringing your pharmacy to your doorstep, offering same-day delivery in metro and major regional areas across Australia. With Chemist2U, managing your health needs is seamless and supportive, all from the comfort of your home.
Have your medication home-delivered by Chemist2U today!
References
[1] https://www.nps.org.au/medicine-finder/valdoxan-tablets
[2] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4128060/
[3] https://www.ema.europa.eu/en/documents/overview/valdoxan-epar-summary-public_en.pdf
[4] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3244295/
[5] https://www.nps.org.au/medicine-finder/valdoxan-tablets
[6] https://annals-general-psychiatry.biomedcentral.com/articles/10.1186/s12991-023-00473-y
[7] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4014359/
[8] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4014359/
[9] https://www.nps.org.au/medicine-finder/valdoxan-tablets
[10] https://www.nps.org.au/medicine-finder/valdoxan-tablets
[11] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3244295/
[12] https://www.nps.org.au/medicine-finder/valdoxan-tablets
