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Some key information about Estalis (estradiol and norethisterone acetate) you need to know

Have you ever wondered, ‘How does Estalis work?’ or ‘What Estalis drug interactions should I know about?’ Read on as Chemist2U, your go-to destination when you need to order from a pharmacy online, breaks down some basics about Estalis (estradiol and norethisterone acetate) in this article.

How does Estalis (estradiol and norethisterone acetate) work?

This product contains both estradiol and norethisterone acetate and is often prescribed for menopausal symptoms that occur in the female reproductive system. Here’s how these two hormones work in this context:

Estradiol

Estradiol is a type of oestrogen that works by changing the transcription of genes in specific organs and tissues, particularly those of the uterus and vagina. Oestrogen is a hormone that binds to specific receptors, which then attach to specific parts of the genes and regulate their activity. This leads to the development, regulation and maintenance of the uterus and vagina, and also plays a role in regulating bone metabolism and other functions in the body.¹

Norethisterone acetate

Norethisterone acetate is a type of progestin. A progestin is a compound that mimics the actions of progesterone, which, like oestrogen, is a steroid hormone regulating hormone levels through a woman’s reproductive cycle. hormone levels.² This is why progestins like norethisterone acetate are often prescribed for menopause therapy.³

How do you take Estalis (estradiol and norethisterone acetate)?

While there are various ways to take estradiol and norethisterone acetate, this product is a transdermal patch. Here are some guidelines on how to take Estalis (estradiol and norethisterone acetate):

• Make sure the skin is dry, cool and clean before application.
• Place the adhesive side on the buttocks or abdomen skin and firmly rub it onto the skin.
• Change the application spot regularly and wait one week before applying to a previously used spot.⁴

Also, you can’t just look up terms like ‘Estalis dosage instructions’. For specific regimen instructions and to find out what dosage is best for you, it’s crucial that you consult your doctor.

Who can take Estalis (estradiol and norethisterone acetate)?

While estradiol and norethisterone acetate have various indications, Estalis (estradiol and norethisterone acetate) was specifically manufactured for the purpose of reducing menopausal symptoms.⁵ However, there are contraindications for estradiol and progestins like norethisterone acetate. So, your doctor may not prescribe this to you if you:

• are at risk of breast cancer or endometrial cancer.
• have a cardiovascular disease.
• are pregnant.
• have angioedema or anaphylactic reaction to estradiol or its components.
• experience abnormal genital bleeding.
• are at risk for cardiovascular disease, DVT, and stroke.
• have a thrombophilic disorder.
• have blood clotting disorders.
• have undergone bariatric surgery.
• have breast cancer.
• have cirrhosis.
• have hepatocellular adenoma or malignant hepatoma.
• experience migraines with aura.⁶⁷

Keep in mind that whether or not you have any of the contraindications above, getting these patches isn’t as simple as looking up ‘Estalis from chemist near me’ and ordering them. You’ll need to consult a doctor for a prescription. During your consultation, communicate your complete medical history so your doctor can make an informed decision about prescribing you the drug.

Side effects of Estalis (estradiol and norethisterone acetate)

If you notice any of the following, tell your doctor or get emergency care immediately:

• Signs of allergy.
• Signs that blood clots may have formed.
• A yellow colour to the skin or eyes, itching, dark-coloured urine or light-coloured bowel motions.
• Pain or tenderness in the abdomen.

Other Estalis (estradiol and norethisterone acetate) side effects include:

• Back pain
• Rise in blood pressure
• Period-like pain
• Weakness or dizziness
• Change in sex drive
• Weight gain
• Headache, migraine
• Nausea, abdominal cramps, vomiting, heartburn, wind and diarrhea
• Breast cancer
• Tingling or numbness
• Tendency to form gallstones
• Depression, nervousness, rapid changes in mood and difficulty sleeping
• Irregular vaginal bleeding or spotting
• Fibroids
• Acne, itchy or dry skin, skin discolouration
• Hair loss
• Tender, painful or swollen breasts
• Inflammatory bowel disease
• Vaginal itching, inflammation or fluid discharge
• Redness, irritation or itching under the patch
• Darkening of the skin, particularly on the face or abdomen
• Abnormal tumour growth related to oestrogens
• Swelling of the lower legs, ankles, fingers or abdomen due to fluid retention
• Skin rash⁸

Side effects vary in urgency and severity, and not all of them may be known or listed in this article. That’s why it’s crucial to consult your doctor immediately for any adverse reactions you may have noticed.

Estalis (estradiol and norethisterone acetate) and other medications

Like all medications, Estalis (estradiol and norethisterone acetate) could potentially be less effective or even dangerous when combined with certain other drugs.

Always keep track of what medications you’re taking and share it with your doctor. This doesn’t just apply to other drugs you need a prescription or escript for; you also need to tell your doctor about any over-the-counter medicines, vitamins and supplements you’re taking.

Medicines you should not use with Estalis (estradiol and norethisterone acetate)

Here are some medications to avoid taking with this drug:

• Phenylbutazone.
• Some epilepsy medicines like phenytoin and carbamazepine.
• Some antibiotics and other antiinfective medicines, such as rifampicin, ketoconazole, erythromycin, rifabutin, nevirapine and efavi.
• Herbal medicines containing St. John’s wort.
• Some drugs for improving sleep, including barbiturates and meprobamate.⁹

There may be other medicines that you’re not allowed to take with this drug, so share all the medications you’re currently taking with your doctor.

How to order home delivery of Estalis (estradiol and norethisterone Acetate) with Chemist2U

At Chemist2U, we’re committed to making medication easy. A crucial part of staying on top of your medication is always having access to a trusted pharmacy. That’s why we have a convenient home delivery service that lets you or your carer easily order your prescription medication from the comfort of home. Here’s how it works:

1. Download the app or use this website. If you’re using an Apple device, you can download our user-friendly app on the App Store or on the Google Play Store if you’re an Android user. You can also shop using our website.
2. Upload your prescriptions online. Just enter your address and contact details, and then under ‘New Script’, upload your prescription. If you’ve already provided your e-prescription before and are just reordering, you can simply reorder.
3. Add other products. Do you need more than just your prescription medications? You can also add over-the-counter medications as well as other products that you would expect at a typical, community pharmacy.
4. Dispensing by local pharmacists. Rest assured, your order will be carefully filled by a qualified pharmacist from a partner pharmacy in your area.
5. Home delivery. We cover all capital cities and major regional areas across Australia. Order before the cutoff for same-day delivery directly from the chemist to your doorstep. (Note that a minority of products, inc. Ozempic and Mounjaro, are delivered via AusPost. Allow 1 to 3 business days for capital cities and major regional centres .)

Have general questions about your medications? Use our Ask a Pharmacist service for general pharmacy advice. For any questions about your chemist delivery and other order-related concerns, contact our customer service team using the web chat icon at the bottom right of this page.

Making your medication easy is our priority. Order home delivery of your prescription medications with Chemist2U today!

References

1. https://www.ncbi.nlm.nih.gov/books/NBK541051/

2. https://www.researchgate.net/publication/11416904_Mechanisms_of_Action_of_Estrogen_and_Progesterone

3. https://www.ncbi.nlm.nih.gov/books/NBK563211

4. https://www.novartis.com/ca-en/sites/novartis_ca/files/estalis_patient_e.pdf

5. https://www.novartis.com/ca-en/sites/novartis_ca/files/estalis_patient_e.pdf

6. https://www.ncbi.nlm.nih.gov/books/NBK549797/#article-21377.s6

7. https://www.ncbi.nlm.nih.gov/books/NBK563211/#article-118745.s6

8. https://www.ebs.tga.gov.au/ebs/picmi/picmirepository.nsf/pdf?OpenAgent&id=CP-2023-CMI-01688-1&d=20240625172310101

9. https://www.ebs.tga.gov.au/ebs/picmi/picmirepository.nsf/pdf?OpenAgent&id=CP-2023-CMI-01690-1