Some important information about Alprim (trimethoprim)
Alprim (trimethoprim) belongs to a class of broad spectrum antibiotics, and it is prescribed to treat urinary tract infections. However, this medication requires a doctor’s prescription and may not be suitable for everyone. The medical review team at Chemist2U has prepared some general information about this medication below.
In this article
How does Alprim (trimethoprim) work?
Alprim (trimethoprim), a medication that may be prescribed as an antibiotic therapy for acute urinary tract infections (UTIs), is thought to operate against a wide spectrum of bacteria.
Its active ingredient, trimethoprim, is studied to be readily absorbed and extensively distributed in body fluids and tissues. Research has found that daily trimethoprim treatment is comparable in efficacy with ampicillin in the treatment of UTIs.[1]
Individuals who are curious about this medication may also be curious about Triprim (trimethoprim), Resprim Forte (sulfamethoxazole/trimethoprim), and other antibiotics. Talk to your doctor to learn the medication that is suitable for your condition.
How do you take Alprim (trimethoprim)?
If this medication has been prescribed to you, it is important to take Alprim (trimethoprim) tablets correctly. Your dosage may vary depending on your doctor’s recommendation, but adults and children over twelve are typically directed to take one tablet daily. The dosages may be different for children aged six to twelve and for the elderly or those with kidney concerns.[2]
Some research has found that short treatment courses, typically three days, may show greater effectiveness than single-dose regimens or seven- to ten-day regimens.[3] However, this may vary depending on a doctor’s advice and an individual’s specific circumstances. It’s important to follow your doctor’s specific usage instructions.
Who can take Alprim (trimethoprim)?
Some individuals may not receive an Alprim (trimethoprim) prescription, as this medication is not suitable for everyone. Specifically, individuals with conditions like porphyria, severe blood disorders, anaemia, or significant kidney issues may be asked by their doctor not to use this medication.[4]
This antibiotic works against the folate cycle, which is crucial for DNA synthesis, which makes it particularly risky during the first trimester of pregnancy due to a potential increase in miscarriage risk, according to research.[5] Thus, those pregnant or planning to become pregnant are typically not advised to take this medication.
For nursing mothers, trimethoprim is known to transfer into breast milk in small amounts, but it is unlikely to cause side effects in the baby.[6] However, since the medication may impact folic acid levels, it’s crucial to have a health consultation with your doctor about your treatment plan.
Side effects of Alprim (trimethoprim)
Like all medications, Alprim (trimethoprim) comes with potential side effects, though they vary from person to person. While many may never encounter these issues, it’s important to be aware and seek medical advice if necessary.
Common side effects can range from epigastric distress, headaches, and nausea to dizziness, sleep disturbances, or joint pain. If you encounter any side effects that concern you, such as skin rashes, unusual bruising, signs of frequent infections, shortness of breath, depression, or blurred vision, it’s essential to communicate with your doctor.[7][8]
Alprim (trimethoprim) and other medications
Individuals who have been prescribed this medication may be curious about Alprim (trimethoprim) and drug interactions. The following medications may affect the efficacy of Alprim (trimethoprim) or increase the risk of side effects.
Notably, combining trimethoprim with pyrimethamine, often used for malaria prevention, may lead to megaloblastic anaemia. Additionally, it can enhance the effects of warfarin and other blood thinners, requiring careful monitoring. Also, if taken with medications like zidovudine, zalcitabine, or lamivudine, trimethoprim could decrease their elimination from the body, raising their blood levels.[9]
This medication may also interact with ACE inhibitors and spironolactone, increasing the risk of elevated potassium levels. Other medications to take note of would be dapsone, phenytoin, and certain antivirals like lamivudine, zalcitabine, and zidovudine. This list does not include all the potential interactions and contraindications, so do consult your doctor for further information.[10]
Medicines you should not use with Alprim (trimethoprim)
When taking Alprim (trimethoprim), you may be asked by your doctor to avoid certain medications. For example, this medication may cause diarrhea as a side effect. Talk to your doctor before taking anti-diarrhea medication.[11]
How to order Alprim (trimethoprim) through Chemist2U
Individuals who are dealing with bacterial infections, pain, or chronic conditions may find it challenging to get the medication they need, when they need it.
Chemist2U strives to make medication management easy. The first step is to download the Chemist2U app or use this website to easily upload your eScript. Once you’ve uploaded your online prescription, browse our selection to add over-the-counter medication and general products you might need – as you would in a physical pharmacy.
Be assured that a trusted partner chemist from your local area will carefully prepare your order. You can order before the cutoff time for same-day delivery straight from the chemist to you (cutoff times may vary per location). A minority of products (including Ozempic and Mounjaro) are delivered via AusPost. It may take five to seven business days for these medications to be delivered.
You can also leverage our Ask a Pharmacist service to ask general questions about your medications.
Order home delivery at Chemist2U today!
References
[1] https://pubmed.ncbi.nlm.nih.gov/7049657/
[2] https://www.ebs.tga.gov.au/ebs/picmi/picmirepository.nsf/pdf?OpenAgent&id=CP-2010-CMI-04927-3&d=20240301172310101
[3] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1071654/
[4] https://www.nps.org.au/medicine-finder/alprim-tablets#what-alprim-is-used-for
[5] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9151599/
[6] https://www.nhs.uk/medicines/trimethoprim/
[7] https://www.nps.org.au/medicine-finder/alprim-tablets
[8] https://www.ebs.tga.gov.au/ebs/picmi/picmirepository.nsf/pdf?OpenAgent&id=CP-2010-CMI-04927-3&d=20240301172310101
[9] https://www.tga.gov.au/resources/artg/63518
[10] https://www.ebs.tga.gov.au/ebs/picmi/picmirepository.nsf/pdf?OpenAgent&id=CP-2010-CMI-04927-3&d=20240301172310101
