Zepbound - (tirzepatide) - Delivery Benefits - Australia

Zepbound (tirzepatide) is a medication generating interest in the management of type 2 diabetes, but it is important to clarify its intended use. Zepbound (tirzepatide) is not approved in Australia; however, other brands of tirzepatide are. Mounjaro (tirzepatide), for example, is approved for the treatment of adults with insufficiently controlled Type 2 diabetes mellitus as an adjunct to diet and exercise.¹

If you’re wondering, ‘how does Zepbound work?’ this article provides an overview of its potential role in managing blood sugar levels. It also highlights important considerations, including possible side effects and interactions.

Zepbound (tirzepatide) is an injectable prescription medication that is intended to support weight management in adults with obesity or those who are overweight and have related medical conditions such as type 2 diabetes or hypertension. This medication is intended to be used in conjunction with a reduced-calorie diet and increased physical activity.²

Tirzepatide, the active ingredient, targets two crucial hormones – GIP (glucose-dependent insulinotropic polypeptide) and GLP-1 (glucagon-like peptide-1) – which are involved in regulating blood sugar and appetite. By activating these pathways, Zepbound (tirzepatide) can potentially help reduce appetite, slow digestion, and improve the body’s ability to manage blood sugar levels.³

How does one take Zepbound (tirzepatide)?

For those prescribed Zepbound (tirzepatide) in other countries, they take the weight loss injection by injecting under the skin.⁴

The doctor guides patients through the correct technique to administer it in the abdomen, thigh or upper arm. Proper administration is crucial because it can help improve the chances of the medication working as intended, and can reduce potential discomfort.

Zepbound is typically taken once a week. The manufacturer advises administering it on the same day each week, providing flexibility as it can be done at any time of the day, with or without food. If a dose is missed, it may be taken within the next four days.⁵

Sticking to the doctor’s instructions is essential. While the manufacturer’s guidelines provide a general protocol, the doctor may tailor the Zepbound dosage specifically for the patient, considering their personal medical history.

Who can take Zepbound (tirzepatide)?

Tirzepatide may be suitable for certain adults based on BMI and health conditions.

According to studies, individuals with a BMI of 30 or higher may consider this medication. Additionally, those with a BMI of 27 or higher who face additional weight-related health challenges like hypertension or cardiovascular disease might also be eligible.⁶

Just as with other weight loss medication options, such as weight loss tablets, medical factors play a role in determining suitability. Doctors may determine if Zepbound (tirzepatide) is suitable for a patient, and this decision will be based on their medical history and current health status.

Side effects of Zepbound (tirzepatide)

Zepbound side effects can vary from common to severe reactions.

Common side effects include nausea, diarrhea, vomiting, constipation, and abdominal pain. These gastrointestinal symptoms are often temporary as the body adjusts to the medication.⁷ However, if the symptoms persist, it’s important to consult a doctor for advice.

In some cases, Zepbound may lead to more severe side effects, such as pancreatitis, low blood sugar, and allergic reactions. An allergic reaction to tirzepatide, although rare, may present as a rash, breathing difficulties, or swelling and should be addressed promptly with medical assistance.⁸

Zepbound (tirzepatide) and other medications

Zepbound (tirzepatide) may interact with other medications, especially those affecting blood sugar levels.

When tirzepatide is used alongside medications like sulfonylureas, there may be an increased risk of hypoglycemia or low blood sugar. This effect occurs because both medications lower blood sugar through different mechanisms, potentially enhancing each other’s actions.⁹

Informing the doctor about all the medications a patient is taking is essential.

Every medication – whether it’s Zepbound (tirzepatide), Wegovy for weight loss, or a different medication – has unique characteristics and potential interactions that can affect one’s health. By providing a comprehensive list of one’s medications, a doctor can better assess possible risks and make necessary adjustments.

Medicines that should not be used with Zepbound (tirzepatide)

Using more than one medication with the active ingredient tirzepatide can lead to unexpected side effects. Such combinations may amplify certain reactions, making them difficult to manage and potentially hazardous to overall health. Additionally, while each medication may be effective on its own, their simultaneous use does not guarantee enhanced efficacy and could interfere with the treatment goals.

If a patient is planning to take Zepbound (tirzepatide) alongside alternatives to Wegovy, for example, talk to their doctor about it first.

A doctor might also warn a patient about taking Zepbound (tirzepatide) with GLP-1 receptor agonists. These medications function similarly, and their combined use could result in additive effects, heightening the risk of negative outcomes. This includes potential issues like severe gastrointestinal problems or unpredictable blood sugar drops.¹⁰

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